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MERIDIA
(sibutramine hydrochloride monohydrate) Capsules contain 5 mg, 10 mg, or 15 mg of
sibutramine hydrochloride monohydrate and are supplied as follows:
- 5 mg, blue/yellow capsules imprinted
with "MERIDIA" on the cap and "-5-" on the body, in bottles of 100
capsules.
- 10 mg, blue/white capsules imprinted
with "MERIDIA" on the cap and "-10-" on the body, in bottles of 100
capsules.
- 15 mg, yellow/white capsules imprinted
with "MERIDIA" on the cap and "-15-" on the body, in bottles of 100
capsules.
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HOW DOES MERIDIA WORK?
Drugs of this class are thought to
suppress appetite by inhibiting the reuptake of serotonin, dopamine and
norepiniphrine thereby modifying appetite centers in the brain.
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HOW TO TAKE MERIDIA:
The recommended starting dose of
MERIDIA is 10-milligrams administered once daily with or without food.
If there is inadequate weight loss, the dose may be titrated after 4 weeks
to a total of 15-milligrams taken once daily. The 5-milligram dose should
be reserved for those patients that do not tolerate the 10-milligram dose.
Blood pressure and heart rate changes should betaken into consideration
when making decisions regarding dose titration. Take this medication as
prescribed. Do not take it more often or longer than directed. Use in
combination with other appetite suppressant medicine is generally not
recommended.
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HOW EFFECTIVE IS MERIDIA?
Patients treated with MERIDIA
while on a reduced calorie diet showed significant weight loss during the
first 6 months of treatment, and significant weight loss was maintained
for one year. In one 12-month study, the average weight loss in patients
taking MERIDIA, 10 mg daily, was about 10 lbs. and in those taking
15 mg daily was about 14 lbs. The average weight loss in persons on only a
reduced calorie diet alone was 3 1/2 lbs. Thus, MERIDIA is proven
effective therapy for the obese patient who needs to lose weight to
decrease morbidity. Nonetheless, the magnitude of the weight loss will
ultimately depend on the degree of concomitant caloric restriction and the
concomitant use of a graded exercise program.
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HOW LONG CAN I CONTINUE TO USE MERIDIA?
MERIDIA is a short-term drug that
helps you to start losing weight and then keep on going when you are ready
to carry on, on your own. Your body starts to build up a resistance to the
effects of MERIDIA after a few weeks of treatment, which is when
you should be well on your way to a new lifestyle and ready to stop
MERIDIA.
Appetite suppressants are not a
substitute for proper diet. For maximum effects, this must be used in
conjunction with a diet and exercise program.
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BE SURE TO TELL US ON YOU MEDICAL
HISTORY/PERSONAL PROFILE IF:
- You have high blood pressure.
- You have an over-active thyroid.
- You have glaucoma.
- You have Diabetes Mellitus.
- You have emotional problems.
- You are pregnant.
- You are currently breast-feeding.
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DRUG INTERACTIONS:
Included on your medical history/personal
profile questionnaire all the medicines you use, (prescription and
nonprescription), especially other weight reducing agents (e.g.,
diethylpropion), drugs that can raise blood pressure such as decongestants
(e.g., pseudoephedrine, phenylpropanolamine), cough suppressants (e.g.,
dextromethorphan), antidepressants (e.g., nefazodone, fluoxetine,
paroxetine, sertraline, fluvoxamine, venlafaxine), lithium, psychiatric
medications (e.g., MAO Inhibitors such as selegiline, moclobemide,
furazolidone, phenelzine, tranylcypromine), drugs for migraines (e.g.,
dihydroergotamine, sumatriptan), tryptophan, certain narcotic pain
relievers (e.g., meperidine, pentazocine, fentanyl), ketoconazole,
erythromycin, high blood pressure medicine or any drugs which can cause
drowsiness, including certain antihistamines (e.g., diphenhydramine),
sedatives and anti-seizure drugs. Antihistamines and decongestants may be
found in many nonprescription drugs for cough and cold. MAO inhibitors and
MERIDIA should not be taken together.
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SIDE EFFECTS:
Dry mouth, sleeplessness, irritability,
back pain, stomach upset or constipation may occur the first few days as
you body adjusts to the medication. Stop MERIDIA if you experience;
rash, hives, seizures, worsening of vision, decreased amount of urine or
unusual bleeding or bruising. Stop MERIDIA immediately if you
experience the following side effects or symptoms of toxicity; excitement,
restlessness, loss of consciousness, confusion, agitation, weakness,
shivering, clumsiness or unsteadiness, fast heartbeat, large-unchanging
pupils, vomiting, trouble breathing, shortness of breath, chest pains,
swelling of feet/ankles or legs, fainting, disorientation, depression,
high fever, eye pain, tremor or increased sweating.
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CONTRAINDICATIONS:
MERIDIA is contraindicated in
patients with arteriosclerosis, cardiovascular disease, and moderate to
severe hypertension.
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